Our publications

Publications 2023

  1. Epitope-based precision immunotherapy of Type 1 diabetes.
    Firdessa Fite R, Bechi Genzano C, Mallone R, Creusot RJ.
    Hum Vaccin Immunother. 2023 Dec 31;19(1):2154098. doi: 10.1080/21645515.2022.2154098. Epub 2023 Jan 19. PMID: 36656048
  2. The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes.
    Roep BO.
    Front Immunol. 2023 Jan 17;14:1112858. doi: 10.3389/fimmu.2023.1112858. eCollection 2023. PMID: 36733487
  3. In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities.
    Halliez C, Ibrahim H, Otonkoski T, Mallone R.
    Front Endocrinol (Lausanne). 2023 Jan 16;13:1076683. doi: 10.3389/fendo.2022.1076683. eCollection 2022. PMID: 36726462 Free PMC article. Review
  4. The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes.
    Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Rodriguez-Calvo T.
    Diabetologia. 2023 Mar 8. doi: 10.1007/s00125-023-05888-6. Online ahead of print. PMID: 36884056
  5. IL-2-based approaches to Treg enhancement.
    Harris F, Berdugo YA, Tree T.
    Clin Exp Immunol. 2023 Mar 16;211(2):149-163. doi: 10.1093/cei/uxac105. PMID: 36399073
  6. Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention.
    Carré A, Vecchio F, Flodstrom-Tullberg M, You S, Mallone R.
    Endocr Rev. 2023 Mar 8:bnad007. doi: 10.1210/endrev/bnad007. Online ahead of print. PMID: 36884282
  7. Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells.
    van Tienhoven R, Kracht MJL, van der Slik AR, Thomaidou S, Wolters AHG, Giepmans BNG, Riojas JPR, Nelson MS, Carlotti F, de Koning EJP, Hoeben RC, Zaldumbide A, Roep BO.
    Diabetologia. 2023 Mar 8. doi: 10.1007/s00125-023-05882-y. Online ahead of print. PMID: 36884057

Publications 2022

  1. The Impact of Pancreatic Head Resection on Blood Glucose Homeostasis in Patients with Chronic Pancreatitis.
    Hempel S, Oehme F, Ehehalt F, Solimena M, Kolbinger FR, Bogner A, Welsch T, Weitz J, Distler M.
    J Clin Med. 2022 Jan 27;11(3):663. doi: 10.3390/jcm11030663. PMID: 35160113
  2. Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
    Balboa D, Barsby T, Lithovius V, Saarimäki-Vire J, Omar-Hmeadi M, Dyachok O, Montaser H, Lund PE, Yang M, Ibrahim H, Näätänen A, Chandra V, Vihinen H, Jokitalo E, Kvist J, Ustinov J, Nieminen AI, Kuuluvainen E, Hietakangas V, Katajisto P, Lau J, Carlsson PO, Barg S, Tengholm A, Otonkoski T.
    Nat Biotechnol. 2022 Mar 3. doi: 10.1038/s41587-022-01219-z. Online ahead of print. PMID: 35241836
  3. Temporal regulation of interferon signalling in human EndoC-βH1 cells.
    Dhayal S, Leslie KA, Baity M, Akhbari P, Richardson SJ, Russell MA, Morgan NG.
    J Mol Endocrinol. 2022 May 1:JME-21-0224. doi: 10.1530/JME-21-0224. Online ahead of print. PMID: 35521765
  4. Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?
    Deligne C, You S, Mallone R.
    J Pers Med. 2022 Mar 29;12(4):542. doi: 10.3390/jpm12040542. PMID: 35455658 Free PMC article. Review.
  5. Distinguishing activated T regulatory cell and T conventional cells by single-cell technologies.
    Reinhardt J, Sharma V, Stavridou A, Lindner A, Reinhardt S, Petzold A, Lesche M, Rost F, Bonifacio E, Eugster A.
    Immunology. 2022 May;166(1):121-137. doi: 10.1111/imm.13460. Epub 2022 Mar 2. PMID: 35196398
  6. Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative Endocrine Cells in Recent Onset Type 1 Diabetic Donors.
    Nigi L, Brusco N, Grieco GE, Fignani D, Licata G, Formichi C, Aiello E, Marselli L, Marchetti P, Krogvold L, Jorgensen KD, Sebastiani G, Dotta F.
    Front Immunol. 2022 Mar 11;13:833141. doi: 10.3389/fimmu.2022.833141. eCollection 2022. PMID: 35359976
  7. Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.
    Yang JHM, Ward-Hartstonge KA, Perry DJ, Blanchfield JL, Posgai AL, Wiedeman AE, Diggins K, Rahman A, Tree TIM, Brusko TM, Levings MK, James EA, Kent SC, Speake C, Homann D, Long SA; Immunology of Diabetes Society T-Cell Cytometry Group.
    Eur J Immunol. 2022 Mar;52(3):372-388. doi: 10.1002/eji.202049067. Epub 2022 Jan 28. PMID: 35025103
  8. INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes.
    Dunger DB, Bruggraber SFA, Mander AP, Marcovecchio ML, Tree T, Chmura PJ, Knip M, Schulte AM, Mathieu C; INNODIA consortium.
    Trials. 2022 May 18;23(1):414. doi: 10.1186/s13063-022-06259-z. PMID: 35585600
  9. Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.
    Gootjes C, Zwaginga JJ, Roep BO, Nikolic T.
    Front Immunol. 2022 May 4;13:886736. doi: 10.3389/fimmu.2022.886736. eCollection 2022. PMID: 35603161 Free PMC article. Review.
  10. Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.
    Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R.
    J Biol Chem. 2022 Jul;298(7):102096. doi: 10.1016/j.jbc.2022.102096. Epub 2022 Jun 2. PMID: 35660019
  11. Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation.
    Grieco GE, Brusco N, Fignani D, Nigi L, Formichi C, Licata G, Marselli L, Marchetti P, Salvini L, Tinti L, Po A, Ferretti E, Sebastiani G, Dotta F.
    Cell Death Discov. 2022 Jul 29;8(1):340. doi: 10.1038/s41420-022-01142-x. PMID: 35906204
  12. Every islet matters: improving the impact of human islet research.
    Gloyn AL, Ibberson M, Marchetti P, Powers AC, Rorsman P, Sander M, Solimena M.
    Nat Metab. 2022 Aug;4(8):970-977. doi: 10.1038/s42255-022-00607-8. Epub 2022 Aug 11. PMID: 35953581 Review.
  13. A classification and regression tree analysis identifies subgroups of childhood type 1 diabetes.
    Achenbach P, Hippich M, Zapardiel-Gonzalo J, Karges B, Holl RW, Petrera A, Bonifacio E, Ziegler AG; DiMelli Study group and DPV Study group.
    EBioMedicine. 2022 Aug;82:104118. doi: 10.1016/j.ebiom.2022.104118. Epub 2022 Jul 5. PMID: 35803018 Free PMC article.
  14. Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.
    Callebaut A, Bruggeman Y, Zamit C, Sodré FMC, Irla M, Mathieu C, Buitinga M, Overbergh L.
    Front Endocrinol (Lausanne). 2022 Jul 26;13:908248. doi: 10.3389/fendo.2022.908248. eCollection 2022. PMID: 35966081
  15. The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.
    Giusti L, Tesi M, Ciregia F, Marselli L, Zallocco L, Suleiman M, De Luca C, Del Guerra S, Zuccarini M, Trerotola M, Eizirik DL, Cnop M, Mazzoni MR, Marchetti P, Lucacchini A, Ronci M.
    Cells. 2022 Aug 8;11(15):2465. doi: 10.3390/cells11152465. PMID: 35954309
  16. Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective.
    Samassa F, Mallone R.
    Curr Opin Endocrinol Diabetes Obes. 2022 Aug 1;29(4):370-378. doi: 10.1097/MED.0000000000000735. Epub 2022 Jul 2. PMID: 35777965 Review.
  17. The Role of Beta Cell Recovery in Type 2 Diabetes Remission.
    Suleiman M, Marselli L, Cnop M, Eizirik DL, De Luca C, Femia FR, Tesi M, Del Guerra S, Marchetti P.
    Int J Mol Sci. 2022 Jul 4;23(13):7435. doi: 10.3390/ijms23137435. PMID: 35806437 Free PMC article. Review.
  18. ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis.
    Vig S, Lambooij JM, Dekkers MC, Otto F, Carlotti F, Guigas B, Zaldumbide A.
    Front Endocrinol (Lausanne). 2022 Sep 12;13:991632. doi: 10.3389/fendo.2022.991632. eCollection 2022. PMID: 36171907
  19. Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways.
    Bosi E, Marchetti P, Rutter GA, Eizirik DL.
    iScience. 2022 Sep 3;25(10):105056. doi: 10.1016/j.isci.2022.105056. eCollection 2022 Oct 21. PMID: 36134336
  20. Family Structure is Associated with Mental Health and Attention Deficit (Hyperactivity) Disorders in Adolescents with Type 1 Diabetes.
    Baechle C, Stahl-Pehe A, Castillo K, Holl RW, Rosenbauer J.
    Exp Clin Endocrinol Diabetes. 2022 Sep;130(9):604-613. doi: 10.1055/a-1729-7972. Epub 2022 Mar 31. PMID: 35359008
  21. Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells.
    Szymczak F, Alvelos MI, Marín-Cañas S, Castela Â, Demine S, Colli ML, Op de Beeck A, Thomaidou S, Marselli L, Zaldumbide A, Marchetti P, Eizirik DL.
    Sci Adv. 2022 Sep 16;8(37):eabn5732. doi: 10.1126/sciadv.abn5732. Epub 2022 Sep 14. PMID: 36103539
  22. In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo.
    Fantuzzi F, Toivonen S, Schiavo AA, Chae H, Tariq M, Sawatani T, Pachera N, Cai Y, Vinci C, Virgilio E, Ladriere L, Suleiman M, Marchetti P, Jonas JC, Gilon P, Eizirik DL, Igoillo-Esteve M, Cnop M.
    Front Cell Dev Biol. 2022 Aug 17;10:967765. doi: 10.3389/fcell.2022.967765. eCollection 2022. PMID: 36060810
  23. Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.
    Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizirik DL, Kent SC, Mallone R, James EA.
    Diabetes. 2022 Oct 6:db220191. doi: 10.2337/db22-0191. Online ahead of print. PMID: 36201618
  24. Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies.
    Yi X, Marmontel de Souza B, Sawatani T, Szymczak F, Marselli L, Marchetti P, Cnop M, Eizirik DL.
    iScience. 2022 Oct 17;25(11):105376. doi: 10.1016/j.isci.2022.105376. eCollection 2022 Nov 18. PMID: 36345338
  25. The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.
    Chandra V, Ibrahim H, Halliez C, Prasad RB, Vecchio F, Dwivedi OP, Kvist J, Balboa D, Saarimäki-Vire J, Montaser H, Barsby T, Lithovius V, Artner I, Gopalakrishnan S, Groop L, Mallone R, Eizirik DL, Otonkoski T.
    Nat Commun. 2022 Oct 26;13(1):6363. doi: 10.1038/s41467-022-34069-z. PMID: 36289205
  26. Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells.
    Kaur S, Frørup C, Mirza AH, Fløyel T, Yarani R, Colli ML, Johannesen J, Størling J, Eizirik DL, Pociot F.
    Noncoding RNA. 2022 Oct 12;8(5):69. doi: 10.3390/ncrna8050069. PMID: 36287121
  27. The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?
    Mallone R, Halliez C, Rui J, Herold KC.
    Diabetes. 2022 Aug 1;71(8):1603-1610. doi: 10.2337/dbi21-0036. PMID: 35881836
  28. Importance of beta cell mass for glycaemic control in people with type 1 diabetes.
    Jansen TJP, Brom M, Boss M, Buitinga M, Tack CJ, van Meijel LA, de Galan BE, Gotthardt M.
    Diabetologia. 2022 Nov 17:1-9 doi: 10.1007/s00125-022-05830-2. Online ahead of print. PMID: 36394644
  29. Conjugation to a cell-penetrating peptide drives the tumour accumulation of the GLP1R antagonist exendin(9-39).
    Collado Camps E, van Lith SAM, Kip A, Frielink C, Joosten L, Brock R, Gotthardt M.
    Eur J Nucl Med Mol Imaging. 2022 Nov 30. doi: 10.1007/s00259-022-06041-y. Online ahead of print. PMID: 36446951
  30. A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.
    Bosi E, Marselli L, Suleiman M, Tesi M, De Luca C, Del Guerra S, Cnop M, Eizirik DL, Marchetti P.
    NAR Genom Bioinform. 2022 Nov 18;4(4):lqac084. doi: 10.1093/nargab/lqac084. eCollection 2022 Dec. PMID: 36415826
  31. Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes.
    Coomans de Brachène A, Scoubeau C, Musuaya AE, Costa-Junior JM, Castela A, Carpentier J, Faoro V, Klass M, Cnop M, Eizirik DL.
    Diabetologia. 2022 Nov 19:1-11. doi: 10.1007/s00125-022-05837-9. Online ahead of print. PMID: 36401627
  32. Single-cell imaging of α and β cell metabolic response to glucose in living human Langerhans islets.
    Azzarello F, Pesce L, De Lorenzi V, Ferri G, Tesi M, Del Guerra S, Marchetti P, Cardarelli F.
    Commun Biol. 2022 Nov 12;5(1):1232. doi: 10.1038/s42003-022-04215-w. PMID: 36371562
  33. ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation.
    Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A.
    Front Endocrinol (Lausanne). 2022 Nov 28;13:1058345. doi: 10.3389/fendo.2022.1058345. eCollection 2022. PMID: 36518246
  34. Pancreatic Islet Cells Response to IFNγ Relies on Their Spatial Location within an Islet.
    De Burghgrave M, Lourenço C, Berthault C, Aiello V, Villalba A, Fouque A, Diedisheim M, You S, Oshima M, Scharfmann R.
    Cells. 2022 Dec 28;12(1):113. doi: 10.3390/cells12010113. PMID: 36611907

Publications 2021

  1. The Landscape of microRNAs in βCell: Between Phenotype Maintenance and Protection.
    Grieco GE, Brusco N, Licata G, Fignani D, Formichi C, Nigi L, Sebastiani G, Dotta F.
    Int J Mol Sci. 2021 Jan 14;22(2):E803. doi: 10.3390/ijms22020803. PMID: 33466949 Review.
  2. Collaboration for rare diabetes: understanding new treatment options for Wolfram syndrome.
    Reschke F, Rohayem J, Maffei P, Dassie F, Schwandt A, de Beaufort C, Toni S, Szypowska A, Cardona-Hernandez R, Datz N, Klee K, Danne T.
    Endocrine. 2021 Feb 1. doi: 10.1007/s12020-021-02622-3. Online ahead of print. PMID: 33527330 Review.
  3. Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis.
    Szymczak F, Colli ML, Mamula MJ, Evans-Molina C, Eizirik DL.
    Sci Adv. 2021 Jan 6;7(2):eabd7600. doi: 10.1126/sciadv.abd7600. Print 2021 Jan. PMID: 33523973
  4. The role of Interleukin-32 in autoimmunity.
    de Albuquerque R, Komsi E, Starskaia I, Ullah U, Lahesmaa R.
    Scand J Immunol. 2021 Feb;93(2):e13012. doi: 10.1111/sji.13012. Epub 2021 Jan 6. PMID: 33336406 Review.
  5. Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.
    Tesi M, Bugliani M, Ferri G, Suleiman M, De Luca C, Bosi E, Masini M, De Tata V, Gysemans C, Cardarelli F, Cnop M, Eizirik DL, Marchetti P, Marselli L.
    Biomolecules. 2021 Feb 19;11(2):320. doi: 10.3390/biom11020320. PMID: 33669901
  6. Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets.
    Rodriguez-Calvo T, Johnson JD, Overbergh L, Dunne JL.
    Front Immunol. 2021 Apr 19;12:667989. doi: 10.3389/fimmu.2021.667989. eCollection 2021. PMID: 33953728
  7. Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes.
    Vig S, Lambooij JM, Zaldumbide A, Guigas B.
    Front Immunol. 2021 Apr 16;12:669492. doi: 10.3389/fimmu.2021.669492. eCollection 2021. PMID: 33936111
  8. Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.
    Bruggeman Y, Sodré FMC, Buitinga M, Mathieu C, Overbergh L, Kracht MJL.
    Expert Opin Ther Targets. 2021 Apr 26. doi: 10.1080/14728222.2021.1918104. Online ahead of print.
  9. Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum.
    Carré A, Mallone R.
    Front Immunol. 2021 Mar 29;12:639682. doi: 10.3389/fimmu.2021.639682. eCollection 2021. PMID: 33854508
  10. A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets.
    Kaur S, Mirza AH, Overgaard AJ, Pociot F, Størling J.
    Front Genet. 2021 Mar 10;12:630109. doi: 10.3389/fgene.2021.630109. eCollection 2021. PMID: 33777101
  11. Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.
    Coomans de Brachène A, Castela A, Musuaya AE, Marselli L, Marchetti P, Eizirik DL.
    Auto Immun Highlights. 2021 Mar 27;12(1):6. doi: 10.1186/s13317-021-00148-2. PMID: 33773604
  12. Arresting or curing type 1 diabetes: an elusive goal, but closing the gap.
    Martens PJ, Gysemans C, Mathieu C.
    J Endocrinol. 2021 Mar 1:JOE-20-0552. doi: 10.1530/JOE-20-0552. Online ahead of print. PMID: 33729180 Review.
  13. The SAgA of Antigen-Specific Immunotherapy for Type 1 Diabetes.
    Mallone R, You S.
    Diabetes. 2021 May 20:dbi210011. doi: 10.2337/dbi21-0011. Online ahead of print. PMID: 34016601
  14. Citrullination and PAD Enzyme Biology in Type 1 Diabetes - Regulators of Inflammation, Autoimmunity, and Pathology.
    Yang ML, Sodré FMC, Mamula MJ, Overbergh L.
    Front Immunol. 2021 Jun 1;12:678953. doi: 10.3389/fimmu.2021.678953. eCollection 2021. PMID: 34140951
  15. Prognostic transcriptome classes of duodenopancreatic neuroendocrine tumors.
    Diedisheim M, Dermine S, Jouinot A, Septier A, Gaujoux S, Dousset B, Cadiot G, Larger E, Bertherat J, Scharfmann R, Terris B, Coriat R, Assié G.
    Endocr Relat Cancer. 2021 Jun 1:ERC-21-0051.R1. doi: 10.1530/ERC-21-0051. Online ahead of print. PMID: 34061769
  16. A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.
    Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL.
    Islets. 2021 Jul 9:1-15. doi: 10.1080/19382014.2021.1948282. Online ahead of print. PMID: 34241569
  17. Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?
    Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA.
    Front Immunol. 2021 Jun 16;12:683091. doi: 10.3389/fimmu.2021.683091. eCollection 2021. PMID: 34220832
  18. Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects.
    Arif S, Pujol-Autonell I, Kamra Y, Williams E, Yusuf N, Domingo-Vila C, Shahrabi Y, Pollock E, Khatri L, Peakman M, Tree T, Lorenc A.
    Front Immunol. 2021 Jun 25;12:675746. doi: 10.3389/fimmu.2021.675746. eCollection 2021. PMID: 34262563
  19. Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.
    Apaolaza PS, Petropoulou PI, Rodriguez-Calvo T.
    Front Mol Biosci. 2021 Jun 11;8:689799. doi: 10.3389/fmolb.2021.689799. eCollection 2021. PMID: 34179094
  20. Protocol to analyze circulating small non-coding RNAs by high-throughput RNA sequencing from human plasma samples.
    Grieco GE, Sebastiani G, Fignani D, Brusco N, Nigi L, Formichi C, Licata G, Bruttini M, D'Aurizio R, Mathieu C, Gysemans C, Dotta F.
    STAR Protoc. 2021 Jun 15;2(3):100606. doi: 10.1016/j.xpro.2021.100606. eCollection 2021 Sep 17. PMID: 34189472
  21. Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?
    Bourgeois S, Sawatani T, Van Mulders A, De Leu N, Heremans Y, Heimberg H, Cnop M, Staels W.
    Cells. 2021 Jan 19;10(1):191. doi: 10.3390/cells10010191. PMID: 33477961
  22. Preventing type 1 diabetes in childhood.
    Dayan CM, Besser REJ, Oram RA, Hagopian W, Vatish M, Bendor-Samuel O, Snape MD, Todd JA.
    Science. 2021 Jul 30;373(6554):506-510. doi: 10.1126/science.abi4742. PMID: 34326231 Review.
  23. The pancreatic β cell response to secretory demands and adaption to stress.
    Kalwat MA, Scheuner D, Rodrigues Dos Santos K, Eizirik DL, Cobb MH.
    Endocrinology. 2021 Aug 18:bqab173. doi: 10.1210/endocr/bqab173. Online ahead of print. PMID: 34407177
  24. Defining a cure for type 1 diabetes: a call to action.
    Roep BO, Montero E, van Tienhoven R, Atkinson MA, Schatz DA, Mathieu C.
    Lancet Diabetes Endocrinol. 2021 Jul 30:S2213-8587(21)00181-9. doi: 10.1016/S2213-8587(21)00181-9. Online ahead of print. PMID: 34339632
  25. Mast Cells and the Pancreas in Human Type 1 and Type 2 Diabetes.
    Masini M, Suleiman M, Novelli M, Marselli L, Marchetti P, De Tata V.
    Cells. 2021 Jul 23;10(8):1875. doi: 10.3390/cells10081875. PMID: 34440644 Review.
  26. Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion.
    Zakaria A, Berthault C, Cosson B, Jung V, Guerrera IC, Rachdi L, Scharfmann R.
    J Biol Chem. 2021 Jul;297(1):100839. doi: 10.1016/j.jbc.2021.100839. Epub 2021 May 27. PMID: 34051232
  27. Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes.
    Corcos N, Culina S, Deligne C, Lavaud C, You S, Mallone R.
    Front Immunol. 2021 Aug 10;12:616215. doi: 10.3389/fimmu.2021.616215. eCollection 2021. PMID: 34447366
  28. From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes.
    Eizirik DL, Szymczak F, Alvelos MI, Martin F.
    Diabetes. 2021 Aug 20:dbi200046. doi: 10.2337/dbi20-0046. Online ahead of print. PMID: 34417266
  29. Long-RNA sequencing and ribosome profiling of inflamed beta-cells reveal an extensive translatome landscape.
    Thomaidou S, Slieker RC, van der Slik AR, Boom J, Mulder F, Munoz-Garcia A, 't Hart LM, Koeleman B, Carlotti F, Hoeben RC, Roep BO, Mei H, Zaldumbide A.
    Diabetes. 2021 Jun 15:db201122. doi: 10.2337/db20-1122. Online ahead of print. PMID: 34554924
  30. Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy.
    Faucher P, Beuvon F, Fignani D, Sebastiani G, Afonso G, Zhou Z, Dousset B, Boitard C, Dotta F, Mallone R, Larger E.
    Diabetologia. 2021 Sep 14. doi: 10.1007/s00125-021-05563-8. Online ahead of print. PMID: 34522983
  31. CD8+ T cells variably recognize native versus citrullinated GRP78 epitopes in type 1 diabetes
    Azoury ME, Samassa F, Buitinga M, Nigi L, Brusco N, Callebaut A, Giraud M, Irla M, Lalanne AI, Carré A, Afonso G, Zhou Z, Brandao B, Colli ML, Sebastiani G, Dotta F, Nakayama M, Eizirik DL, You S, Pinto S, Mamula MJ, Verdier Y, Vinh J, Buus S, Mathieu C, Overbergh L, Mallone R.
    Diabetes. 2021 Sep 24;db210259. doi: 10.2337/db21-0259. Online ahead of print.
  32. A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes.
    Luce S, Guinoiseau S, Gadault A, Letourneur F, Nitschke P, Bras M, Vidaud M, Charneau P, Larger E, Colli ML, Eizirik DL, Lemonnier F, Boitard C.
    Front Immunol. 2021 Oct 14;12:748679. doi: 10.3389/fimmu.2021.748679. eCollection 2021. PMID: 34721418
  33. Extracellular Vesicles in Immune System Regulation and Type 1 Diabetes: Cell-to-Cell Communication Mediators, Disease Biomarkers, and Promising Therapeutic Tools.
    Grieco GE, Fignani D, Formichi C, Nigi L, Licata G, Maccora C, Brusco N, Sebastiani G, Dotta F.
    Front Immunol. 2021 Jun 9;12:682948. doi: 10.3389/fimmu.2021.682948. eCollection 2021. PMID: 34177928
  34. Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas.
    Brusko TM, Mallone R, Rodriguez-Calvo T.
    Front Endocrinol (Lausanne). 2021 Oct 14;12:767012. doi: 10.3389/fendo.2021.767012. eCollection 2021. PMID: 34721308
  35. Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.
    Frørup C, Mirza AH, Yarani R, Nielsen LB, Mathiesen ER, Damm P, Svare J, Engelbrekt C, Størling J, Johannesen J, Mortensen HB, Pociot F, Kaur S.
    Front Immunol. 2021 Oct 8;12:744509. doi: 10.3389/fimmu.2021.744509. eCollection 2021. PMID: 34691048
  36. Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes.
    Wilhelm-Benartzi CS, Miller SE, Bruggraber S, Picton D, Wilson M, Gatley K, Chhabra A, Marcovecchio ML, Hendriks AEJ, Morobé H, Chmura PJ, Bond S, Aschemeier-Fuchs B, Knip M, Tree T, Overbergh L, Pall J, Arnaud O, Haller MJ, Nitsche A, Schulte AM, Mathieu C, Mander A, Dunger D.
    BMJ Open. 2021 Dec 7;11(12):e053669. doi: 10.1136/bmjopen-2021-053669. PMID: 34876434
  37. Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells.
    Buchacher T, Honkimaa A, Välikangas T, Lietzén N, Hirvonen MK, Laiho JE, Sioofy-Khojine AB, Eskelinen EL, Hyöty H, Elo LL, Lahesmaa R.
    iScience. 2021 Dec 18;25(1):103653. doi: 10.1016/j.isci.2021.103653. eCollection 2022 Jan 21. PMID: 35024587
  38. 100 Years of Insulin: Lifesaver, immune target, and potential remedy for prevention.
    Ziegler AG, Danne T, Daniel C, Bonifacio E.
    Med (N Y). 2021 Oct 8;2(10):1120-1137. doi: 10.1016/j.medj.2021.08.003. Epub 2021 Sep 15. PMID: 34993499
  39. A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes.
    Marwaha AK, Chow S, Pesenacker AM, Cook L, Sun A, Long SA, Yang JHM, Ward-Hartstonge KA, Williams E, Domingo-Vila C, Halani K, Harris KM, Tree TIM, Levings MK, Elliott T, Tan R, Dutz JP.
    mmunother Adv. 2021 Nov 13;2(1):ltab022. doi: 10.1093/immadv/ltab022. eCollection 2022. PMID: 35072168

Publications 2020

  1. Beta-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Post-Transcriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1
    Thomaidou S, Kracht MJL, van der Slik A, Laban S, de Koning EJ, Carlotti F, Hoeben RC, Roep BO, Zaldumbide A
    Diabetes. 2020 Jan 2. pii: db190984. doi: 10.2337/db19-0984. [Epub ahead of print]
  2. Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
    Demine S, Schiavo AA, Marín-Cañas S, Marchetti P, Cnop M, Eizirik DL.
    Stem Cell Res Ther. 2020 Jan 3;11(1):7. doi: 10.1186/s13287-019-1523-3.
  3. Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention
    Nakayasu ES, Syed F, Tersey SA, Gritsenko MA, Mitchell HD, Chan CY, Dirice E, Turatsinze JV, Cui Y, Kulkarni RN, Eizirik DL, Qian WJ, Webb-Robertson BM, Evans-Molina C, Mirmira RG, Metz TO
    Cell Metab. 2020 Jan 8. pii: S1550-4131(19)30670-9. doi: 10.1016/j.cmet.2019.12.005. [Epub ahead of print]
  4. A Genetic Screen Identifies Crat As A Regulator Of Pancreatic Beta-Cell Insulin Secretion
    Berdous D, Berney X, Sanchez-Archidona AR, Jan M, Roujeau C, Mejia IL, Mynatt R, Thorens B.
    Mol Metab. 2020 Apr 13:100993. doi: 10.1016/j.molmet.2020.100993. [Epub ahead of print]
  5. Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes
    Tesovnik T, Kovač J, Pohar K, Hudoklin S, Dovč K, Bratina N, Trebušak Podkrajšek K, Debeljak M, Veranič P, Bosi E, Piemonti L, Ihan A, Battelino T
    Front Cell Dev Biol. 2020 Mar 31;8:202. doi: 10.3389/fcell.2020.00202. eCollection 2020.
  6. Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis
    Cohrs CM, Panzer JK, Drotar DM, Enos SJ, Kipke N, Chen C, Bozsak R, Schöniger E, Ehehalt F, Distler M, Brennand A, Bornstein SR, Weitz J, Solimena M, Speier S
    Cell Rep. 2020 Apr 7;31(1):107469. doi: 10.1016/j.celrep.2020.03.033.
  7. International benchmarking in type 1 diabetes: Large difference in childhood HbA1c between eight high-income countries but similar rise during adolescence-A quality registry study
    Anderzén J, Hermann JM, Samuelsson U, Charalampopoulos D, Svensson J, Skrivarhaug T, Fröhlich-Reiterer E, Maahs DM, Akesson K, Kapellen T, Fritsch M, Birkebaek NH, Drivvoll AK, Miller K, Stephenson T, Hofer SE, Fredheim S, Kummernes SJ, Foster N, Amin R, Hilgard D, Rami-Merhar B, Dahl-Jørgensen K, Clements M, Hanas R, Holl RW, Warner JT
    Pediatr Diabetes. 2020 Apr 6. doi: 10.1111/pedi.13014. [Epub ahead of print]
  8. Klf6 protects β-cells against insulin resistance-induced dedifferentiation
    Dumayne C1, Tarussio D2, Sanchez-Archidona AR3, Picard A4, Basco D5, Berney XP6, Ibberson M7, Thorens B8.
    Mol Metab. 2020 May;35:100958. doi: 10.1016/j.molmet.2020.02.001. Epub 2020 Feb 6.
  9. An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
    Colli ML, Ramos-Rodríguez M, Nakayasu ES, Alvelos MI, Lopes M, Hill JLE, Turatsinze JV, Coomans de Brachène A, Russell MA, Raurell-Vila H, Castela A, Juan-Mateu J, Webb-Robertson BM, Krogvold L, Dahl-Jorgensen K, Marselli L, Marchetti P, Richardson SJ, Morgan NG, Metz TO, Pasquali L, Eizirik DL.
    Nat Commun. 2020 May 22;11(1):2584. doi: 10.1038/s41467-020-16327-0.
  10. A Direct Look at the Dysfunction and Pathology of the β Cells in Human Type 2 Diabetes
    Marchetti P, Suleiman M, De Luca C, Baronti W, Bosi E, Marselli L.
    Semin Cell Dev Biol. 2020 May 13. pii: S1084-9521(19)30053-9. doi: 10.1016/j.semcdb.2020.04.005. [Epub ahead of print] Review.
  11. Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure.
    Eizirik DL, Pasquali L, Cnop M.
    Nat Rev Endocrinol. 2020 May 12. doi: 10.1038/s41574-020-0355-7. [Epub ahead of print] Review.
  12. Costimulation Blockade Disrupts CD4+ T Cell Memory Pathways and Uncouples Their Link to Decline in β-Cell Function in Type 1 Diabetes.
    Eichmann M, Baptista R, Ellis RJ, Heck S, Peakman M, Beam CA.
    J Immunol. 2020 May 13. pii: ji1901439. doi: 10.4049/jimmunol.1901439. [Epub ahead of print]
  13. Pre-clinical evaluation of TYK2 inhibitors for human beta cell protection in type 1 diabetes.
    Coomans de Brachène A, Castela A, Op de Beeck A, Mirmira RG, Marselli L, Marchetti P, Masse C, Miao W, Leit S, Evans-Molina C, Eizirik DL.
    Diabetes Obes Metab. 2020 Jun 1. doi: 10.1111/dom.14104. [Epub ahead of print]
  14. International benchmarking in type 1 diabetes: Large difference in childhood HbA1c between 8 high-income countries but similar rise during adolescence-A quality registry study.
    Anderzén J, Hermann JM, Samuelsson U, Charalampopoulos D, Svensson J, Skrivarhaug T, Fröhlich-Reiterer E, Maahs DM, Akesson K, Kapellen T, Fritsch M, Birkebaek NH, Drivvoll AK, Miller K, Stephenson T, Hofer SE, Fredheim S, Kummernes SJ, Foster N, Amin R, Hilgard D, Rami-Merhar B, Dahl-Jørgensen K, Clements M, Hanas R, Holl RW, Warner JT.
    Pediatr Diabetes. 2020 Apr 6. doi: 10.1111/pedi.13014. [Epub ahead of print]
  15. T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal.
    James EA, Mallone R, Kent SC, DiLorenzo TP.
    Diabetes. 2020 Jul;69(7):1311-1335. doi: 10.2337/dbi19-0022.
  16. Nanoencapsulated human pancreatic islets for β-cell replacement in Type 1 diabetes
    Krol S, Baronti W, Marchetti P.
    Nanomedicine. 2020 Jul 16. doi: 10.2217/nnm-2020-0166.
  17. Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.
    Syed F, Tersey SA, Turatsinze JV, Felton JL, Kang NJ, Nelson JB, Sims EK, Defrance M, Bizet M, Fuks F, Cnop M, Bugliani M, Marchetti P, Ziegler AG, Bonifacio E, Webb-Robertson BJ, Balamurugan AN, Evans-Molina C, Eizirik DL, Mather KJ, Arslanian S, Mirmira RG.
    Clin Epigenetics. 2020 Jul 31;12(1):116. doi: 10.1186/s13148-020-00906-5.
  18. Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta-cells.
    Berthault C, Staels W, Scharfmann R.
    Mol Metab. 2020 Aug 4:101060. doi: 10.1016/j.molmet.2020.101060. Online ahead of print.
  19. Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets.
    Rachdi L, Maugein A, Pechberty S, Armanet M, Hamroune J, Ravassard P, Marullo S, Albagli O, Scharfmann R.
    Sci Rep. 2020 Aug 10;10(1):13469. doi: 10.1038/s41598-020-69758-6.
  20. Psychological care in children and adolescents with type 1 diabetes in a real‐world setting and associations with metabolic control
    Angela Galler, Dörte Hilgard , Esther Bollow , Thomas Hermann, Nicole Kretschmer, Berthold Maier, Kirsten Mönkemöller, Ralf Schiel, Reinhard W Holl
    Pediatr Diabetes. 2020 Sep;21(6):1050-1058. doi: 10.1111/pedi.13065. Epub 2020 Jul 8.
  21. Glycemic variability - the danger of a physiologically stable metric.
    Battelino T, Dovč K.
    J Clin Endocrinol Metab. 2020 Aug 9:dgaa486. doi: 10.1210/clinem/dgaa486. Online ahead of print.
  22. Revisiting the role of inflammation in the loss of pancreatic β-cells in T1DM.
    Eizirik DL, Colli ML.
    Nat Rev Endocrinol. 2020 Aug 28. doi: 10.1038/s41574-020-00409-6. Online ahead of print.
  23. Transcription factors that shape the mammalian pancreas.
    Jennings RE, Scharfmann R, Staels W.
    Diabetologia. 2020 Oct;63(10):1974-1980. doi: 10.1007/s00125-020-05161-0. Epub 2020 Sep 7.
  24. Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?
    Mallone R, Eizirik DL.
    Diabetologia. 2020 Oct;63(10):1999-2006. doi: 10.1007/s00125-020-05176-7. Epub 2020 Sep 7.
  25. The making of insulin in health and disease.
    Vasiljević J, Torkko JM, Knoch KP, Solimena M.
    Diabetologia. 2020 Oct;63(10):1981-1989. doi: 10.1007/s00125-020-05192-7. Epub 2020 Sep 7.
  26. Peptides Derived From Insulin Granule Proteins are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice.
    Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R.
    Diabetes. 2020 Sep 14:db200013. doi: 10.2337/db20-0013. Online ahead of print.
  27. Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
    Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M.
    Diabetes Care. 2020 Jan;43(1):5-12. doi: 10.2337/dc19-0880. Epub 2019 Nov 21. PMID: 31753960
  28. Beta Cell Imaging-From Pre-Clinical Validation to First in Man Testing.
    Demine S, Schulte ML, Territo PR, Eizirik DL.
    Int J Mol Sci. 2020 Oct 1;21(19):E7274. doi: 10.3390/ijms21197274. PMID: 33019671 Review.
  29. Continuous Glucose Monitoring-Derived Data Report-Simply a Better Management Tool.
    Battelino T, Bergenstal RM.
    Diabetes Care. 2020 Oct;43(10):2327-2329. doi: 10.2337/dci20-0032. PMID: 32958615
  30. Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?
    Carré A, Richardson SJ, Larger E, Mallone R.
    Diabetologia. 2020 Oct 21. doi: 10.1007/s00125-020-05298-y. Online ahead of print. PMID: 33084970 Review.
  31. Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes.
    Nigi L, Brusco N, Grieco GE, Licata G, Krogvold L, Marselli L, Gysemans C, Overbergh L, Marchetti P, Mathieu C, Dahl Jørgensen K, Sebastiani G, Dotta F.
    Front Endocrinol (Lausanne). 2020 Sep 15;11:630. doi: 10.3389/fendo.2020.00630. eCollection 2020. PMID: 33042009 Free PMC article.
  32. Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes.
    Colli ML, Szymczak F, Eizirik DL.
    Front Endocrinol (Lausanne). 2020 Sep 15;11:568446. doi: 10.3389/fendo.2020.568446. eCollection 2020. PMID: 33042023
  33. A circular RNA generated from an intron of the insulin gene controls insulin secretion
    Stoll L, Rodríguez-Trejo A, Guay C, Brozzi F, Bayazit MB, Gattesco S, Menoud V, Sobel J, Marques AC, Venø MT, Esguerra JLS, Barghouth M, Suleiman M, Marselli L, Kjems J, Eliasson L, Renström E, Bouzakri K, Pinget M, Marchetti P, Regazzi R.
    Nat Commun. 2020 Nov 5;11(1):5611. doi: 10.1038/s41467-020-19381-w.
  34. YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress
    De Franco E, Lytrivi M, Ibrahim H, Montaser H, Wakeling MN, Fantuzzi F, Patel K, Demarez C, Cai Y, Igoillo-Esteve M, Cosentino C, Lithovius V, Vihinen H, Jokitalo E, Laver TW, Johnson MB, Sawatani T, Shakeri H, Pachera N, Haliloglu B, Ozbek MN, Unal E, Yıldırım R, Godbole T, Yildiz M, Aydin B, Bilheu A, Suzuki I, Flanagan SE, Vanderhaeghen P, Senée V, Julier C, Marchetti P, Eizirik DL, Ellard S, Saarimäki-Vire J, Otonkoski T, Cnop M, Hattersley AT.
    J Clin Invest. 2020 Nov 9:141455. doi: 10.1172/JCI141455. Online ahead of print.
  35. Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice.
    Sodré FMC, Bissenova S, Bruggeman Y, Tilvawala R, Cook DP, Berthault C, Mondal S, Callebaut A, You S, Scharfmann R, Mallone R, Thompson PR, Mathieu C, Buitinga M, Overbergh L.
    Diabetes. 2020 Nov 17:db200421. doi: 10.2337/db20-0421. Online ahead of print. PMID: 33203696
  36. SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature.
    Fignani D, Licata G, Brusco N, Nigi L, Grieco GE, Marselli L, Overbergh L, Gysemans C, Colli ML, Marchetti P, Mathieu C, Eizirik DL, Sebastiani G, Dotta F.
    Front Endocrinol (Lausanne). 2020 Nov 13;11:596898. doi: 10.3389/fendo.2020.596898. eCollection 2020. PMID: 33281748 Free PMC article.
  37. Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.
    Marselli L, Piron A, Suleiman M, Colli ML, Yi X, Khamis A, Carrat GR, Rutter GA, Bugliani M, Giusti L, Ronci M, Ibberson M, Turatsinze JV, Boggi U, De Simone P, De Tata V, Lopes M, Nasteska D, De Luca C, Tesi M, Bosi E, Singh P, Campani D, Schulte AM, Solimena M, Hecht P, Rady B, Bakaj I, Pocai A, Norquay L, Thorens B, Canouil M, Froguel P, Eizirik DL, Cnop M, Marchetti P.
    Cell Rep. 2020 Dec 1;33(9):108466. doi: 10.1016/j.celrep.2020.108466. PMID: 33264613
  38. Association of family structure with type 1 diabetes management and outcomes in adolescents: a population-based cross-sectional survey.
    Baechle C, Stahl-Pehe A, Castillo K, Selinski S, Holl RW, Rosenbauer J.
    Pediatr Diabetes. 2020 Dec 1. doi: 10.1111/pedi.13166. Online ahead of print. PMID: 33259124
  39. 3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells.
    Müller A, Schmidt D, Xu CS, Pang S, D'Costa JV, Kretschmar S, Münster C, Kurth T, Jug F, Weigert M, Hess HF, Solimena M.
    J Cell Biol. 2021 Feb 1;220(2):e202010039. doi: 10.1083/jcb.202010039. PMID: 33326005
  40. The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.
    Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K, Eizirik DL.
    Life Sci Alliance. 2020 Dec 29;4(3):e202000825. doi: 10.26508/lsa.202000825. Print 2021 Mar. PMID: 33376132
  41. Identification of Deamidated Peptides in Cytokine-Exposed MIN6 Cells through LC-MS/MS Using a Shortened Digestion Time and Inspection of MS2 Spectra.
    Callebaut A, Derua R, Vig S, Delong T, Mathieu C, Overbergh L.
    J Proteome Res. 2020 Dec 29. doi: 10.1021/acs.jproteome.0c00801. Online ahead of print. PMID: 33372785
  42. Noninvasive Monitoring of Glycemia-Induced Regulation of GLP-1R Expression in Murine and Human Islets of Langerhans.
    Buitinga M, Cohrs CM, Eter WA, Claessens-Joosten L, Frielink C, Bos D, Sandker G, Brom M, Speier S, Gotthardt M.
    Diabetes. 2020 Nov;69(11):2246-2252. doi: 10.2337/db20-0616. Epub 2020 Aug 25. PMID: 32843570
  43. Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes.
    Bosi E, Marselli L, De Luca C, Suleiman M, Tesi M, Ibberson M, Eizirik DL, Cnop M, Marchetti P.
    NAR Genom Bioinform. 2020 Nov 20;2(4):lqaa097. doi: 10.1093/nargab/lqaa097. eCollection 2020 Dec. PMID: 33575641

Publications 2019

  1. Capturing residual beta cell function in type 1 diabetes.
    Pociot F
    Diabetologia. 2019 Jan;62(1):28-32. doi: 10.1007/s00125-018-4768-y. Epub 2018 Nov 3. PMID: 30392045
  2. Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells.
    Vig S, Buitinga M, Rondas D, Crèvecoeur I, van Zandvoort M, Waelkens E, Eizirik DL, Gysemans C, Baatsen P, Mathieu C, Overbergh L.
    Cell Death Dis. 2019 Apr 5;10(4): 309 doi: 10.1038/s41419-019-1518-0. PMID: 30952835
  3. Genome editing of human pancreatic beta cell models: problems, possibilities and outlook
    Diego Balboa, Rashmi B. Prasad, Leif Groop, Timo Otonkoski
    Diabetologia. 2019 Jun 3. doi: 10.1007/s00125-019-4908-z. [Epub ahead of print]
  4. The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes
    Ernesto S. Nakayasu, Wei-Jun Qian, Carmella Evans-Molina, Raghavendra G. Mirmira, Decio L. Eizirik & Thomas O. Metz
    Expert Review of Proteomics, 24 june 2019 doi: DOI: 10.1080/14789450.2019.1634548
  5. The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells.
    Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi , Jonas Juan-Mateu , Marco Bugliani, Piero Marchetti and Décio L Eizirik
    Journal of Molecular Endocrinology 2019 July 1. doi: 10.1530/JME-19-0066. [Epub ahead of print]
  6. Center Size and Glycemic Control: An International Study With 504 Centers From Seven Countries
    Birkebaek NH, Hermann JM, Hanberger L, Charalampopoulos D, Holl RW, Skrivarhaug T, Aakesson K, Warner J, Drivvoll AK, Svensson AM, Stephenson T, Hofer SE, Fredheim S, Kummernes SJ, Amin R, Rami-Merhar B, Johansen A, Kapellen TM, Hilgard D, Dahl-Jørgensen K, Froehlich-Reiterer E, Fritsch M, Hanas R, Svensson J.
    Diabetes Care. 2019 Mar;42(3):e37-e39. doi: 10.2337/dc18-1253. Epub 2019 Jan 18. PMID: 30659071
  7. Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes
    Khamis A, Canouil M, Siddiq A, Crouch H, Falchi M, Bulow MV, Ehehalt F, Marselli L, Distler M, Richter D, Weitz J, Bokvist K, Xenarios I, Thorens B, Schulte AM, Ibberson M, Bonnefond A, Marchetti P, Solimena M, Froguel P.
    Mol Metab. 2019 Jun;24:98-107. doi: 10.1016/j.molmet.2019.03.004. Epub 2019 Mar 18. PMID: 30956117
  8. ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor
    Toledo PL, Torkko JM, Müller A, Wegbrod C, Sönmez A, Solimena M, Ermácora MR
    J Biol Chem. 2019 May 24;294(21):8564-8576. doi: 10.1074/jbc.RA119.007607. Epub 2019 Apr 12. PMID: 30979722
  9. Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation
    Henriksson J, Chen X, Gomes T, Ullah U, Meyer KB, Miragaia R, Duddy G, Pramanik J, Yusa K, Lahesmaa R, Teichmann SA
    Cell. 2019 Feb 7;176(4):882-896.e18. doi: 10.1016/j.cell.2018.11.044. Epub 2019 Jan 10. PMID: 30639098
  10. Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization
    Tripathi SK, Välikangas T, Shetty A, Khan MM, Moulder R, Bhosale SD, Komsi E, Salo V, De Albuquerque RS, Rasool O, Galande S, Elo LL, Lahesmaa R.
    iScience. 2019 Jan 25;11:334-355. doi: 10.1016/j.isci.2018.12.020. Epub 2018 Dec 26. PMID: 30641411
  11. CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases
    Singh DD, Hawkins RD, Lahesmaa R, Tripathi SK.
    Semin Cell Dev Biol. 2019 Jun 19. pii: S1084-9521(18)30111-3. doi: 10.1016/j.semcdb.2019.05.007. [Epub ahead of print]. PMID: 31112800
  12. Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells
    Lietzén N, Hirvonen K, Honkimaa A, Buchacher T, Laiho JE, Oikarinen S, Mazur MA, Flodström-Tullberg M, Dufour E, Sioofy-Khojine AB, Hyöty H, Lahesmaa R
    iScience. 2019 Jul 29;19:340-357. doi: 10.1016/j.isci.2019.07.040. [Epub ahead of print]. PMID: 31404834
  13. Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells
    Colli ML, Paula FM, Marselli L, Marchetti P, Roivainen M, Eizirik DL, Op de Beeck A
    J Innate Immun. 2019;11(4):375-390. doi: 10.1159/000496034. Epub 2019 Feb 20. PMID: 30799417
  14. Mixed‐meal tolerance test to assess residual beta‐cell secretion: Beyond the area‐under‐curve of plasma C‐peptide concentration
    Ruan Y, Willemsen RH, Wilinska ME, Tauschmann M, Dunger DB, Hovorka R
    Pediatr Diabetes. 2019 May;20(3):282-285. doi: 10.1111/pedi.12816. Epub 2019 Feb 19. PMID: 30652426
  15. Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes
    Khamis A, Canouil M, Siddiq A, Crouch H, Falchi M, Bulow MV, Ehehalt F, Marselli L, Distler M, Richter D, Weitz J, Bokvist K, Xenarios I, Thorens B, Schulte AM, Ibberson M, Bonnefond A, Marchetti P, Solimena M, Froguel P
    Mol Metab. 2019 Jun;24:98-107. doi: 10.1016/j.molmet.2019.03.004. Epub 2019 Mar 18. PMID: 30956117
  16. Fostering improved human islet research: a European perspective
    Marchetti P, Schulte AM, Marselli L, Schoniger E, Bugliani M, Kramer W, Overbergh L, Ullrich S, Gloyn AL, Ibberson M, Rutter G, Froguel P, Groop L, McCarthy MI, Dotta F, Scharfmann R, Magnan C, Eizirik DL, Mathieu C, Cnop M, Thorens B, Solimena M
    Diabetologia. 2019 Aug;62(8):1514-1516. doi: 10.1007/s00125-019-4911-4. Epub 2019 Jun 13. PMID: 31197398
  17. The supply chain of human pancreatic β cell lines
    Raphael Scharfmann, Willem Staels, Olivier Albagli
    J Clin Invest. 2019 Sep 3;129(9):3511-3520.
  18. PET-based dosimetry of [68Ga]Ga-NODAGA-exendin-4 in humans, a tracer for beta cell imaging
    Boss M, Buitinga M, Jansen TJ, Brom M, Visser EP, Gotthardt M.
    J Nucl Med. 2019 Sep 13. pii: jnumed.119.228627. doi: 10.2967/jnumed.119.228627. [Epub ahead of print]
  19. Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease
    Verhagen J, Yusuf N, Smith EL, Whettlock EM, Naran K, Arif S, Peakman M.
    Diabetologia. 2019 Oct 14. doi: 10.1007/s00125-019-04994-8. [Epub ahead of print]
  20. Bioluminescent reporter assay for monitoring ER stress in human beta cells
    Kracht MJL, de Koning EJP, Hoeben RC, Roep BO, Zaldumbide A.
    Sci Rep. 2018 Dec 10;8(1):17738. doi: 10.1038/s41598-018-36142-4.
  21. The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes.
    Ramos-Rodríguez M, Raurell-Vila H, Colli ML, Alvelos MI, Subirana-Granés M, Juan-Mateu J, Norris R, Turatsinze JV, Nakayasu ES, Webb-Robertson BM, Inshaw JRJ, Marchetti P, Piemonti L, Esteller M, Todd JA, Metz TO, Eizirik DL, Pasquali L.
    Nat Genet. 2019 Nov 1. doi: 10.1038/s41588-019-0524-6. [Epub ahead of print]
  22. miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes
    Ventriglia G, Mancarella F, Sebastiani G, Cook DP, Mallone R, Mathieu C, Gysemans C, Dotta F.
    Diabetologia. 2019 Oct 28. doi: 10.1007/s00125-019-05026-1. [Epub ahead of print]
  23. Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes
    Yeo L, Pujol-Autonell I, Baptista R, Eichmann M, Kronenberg-Versteeg D, Heck S, Dolton G, Sewell AK, Härkönen T, Mikk ML, Toppari J, Veijola R, Knip M, Ilonen J, Peakman M.
    Clin Exp Immunol. 2019 Oct 29. doi: 10.1111/cei.13391. [Epub ahead of print]
  24. Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs
    Mirza AH, Kaur S, Nielsen LB, Størling J, Yarani R, Roursgaard M, Mathiesen ER, Damm P, Svare J, Mortensen HB, Pociot F.
    Front Immunol. 2019 Oct 25;10:2543. doi: 10.3389/fimmu.2019.02543. eCollection 2019.
  25. Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry.
    Yang JHM, Khatri L, Mickunas M, Williams E, Tatovic D, Alhadj Ali M, Young P, Moyle P, Sahni V, Wang R, Kaur R, Tannahill GM, Beaton AR, Gerlag DM, Savage COS, Napolitano Rosen A, Waldron-Lynch F, Dayan CM, Tree TIM.
    Front Immunol. 2019 Oct 31;10:2547. doi: 10.3389/fimmu.2019.02547. eCollection 2019.
  26. Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity
    Oshima M, Pechberty S, Bellini L, Göpel SO, Campana M, Rouch C, Dairou J, Cosentino C, Fantuzzi F, Toivonen S, Marchetti P, Magnan C, Cnop M, Le Stunff H, Scharfmann R.
    Diabetologia. 2019 Dec 3. doi: 10.1007/s00125-019-05046-x. [Epub ahead of print]
  27. MiR-375-mediated suppression of engineered coxsackievirus B3 in pancreatic cells
    Pryshliak M, Hazini A, Knoch K, Dieringer B, Tolksdorf B, Solimena M, Kurreck J, Pinkert S, Fechner H.
    FEBS Lett. 2019 Oct 23. doi: 10.1002/1873-3468.13647. [Epub ahead of print]
  28. Development of a New Mouse Model for Coxsackievirus-Induced Myocarditis by Attenuating Coxsackievirus B3 Virulence in the Pancreas
    Pinkert S, Pryshliak M, Pappritz K, Knoch K, Hazini A, Dieringer B, Schaar K, Dong F, Hinze L, Lin J, Lassner D, Klopfleisch R, Solimena M, Tschöpe C, Kaya Z, Beling A, Kurreck J, van Linthout S, Klingel K, Fechner H.
    Cardiovasc Res. 2019 Oct 9. pii: cvz259. doi: 10.1093/cvr/cvz259. [Epub ahead of print]
  29. A nanobody-based nuclear imaging tracer targeting dipeptidyl peptidase 6 to determine the mass of human beta cell grafts in mice
    Demine S, Garcia Ribeiro R, Thevenet J, Marselli L, Marchetti P, Pattou F3, Kerr-Conte J, Devoogdt N, Eizirik DL.
    Diabetologia. 2019 Dec 23. doi: 10.1007/s00125-019-05068-5. [Epub ahead of print]
  30. Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes
    Grieco GE, Brusco N, Licata G, Nigi L, Formichi C, Dotta F, Sebastiani G.
    Int J Mol Sci. 2019 Dec 17;20(24). pii: E6358. doi: 10.3390/ijms20246358.
  31. From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage.
    Nigi L, Maccora C, Dotta F, Sebastiani G.
    Diabetes Metab Res Rev. 2019 Dec 18:e3264. doi: 10.1002/dmrr.3264. [Epub ahead of print]

Publications 2018

  1. Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis
    Paula FMM, Leite NC, Borck PC, Freitas-Dias R, Cnop M, Chacon-Mikahil MPT, Cavaglieri CR, Marchetti P, Boschero AC, Zoppi CC, Eizirik DL. FASEB J.
    2018 Jan 3:fj201700710R.
  2. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
    Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.
    Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013.
  3. Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicentre DPV study on 24,011 patients from Germany, Austria, or Luxembourg
    Bohn B, Mönkemöller K, Hilgard D, Dost A, Schwab KO, Lilienthal E, Hammer E, Hake K, Fritsch M, Gohlke B, de Beaufort C, Holl RW; DPV-initiative.
    Pediatr Diabetes. 2018 Feb 7.
  4. DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes
    Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, Grano F, Cardarelli F, Boggi U, Vistoli F, Filipponi F, De Simone P, Marselli L, De Tata V, Ahren B, Eizirik DL, Marchetti P.. Mol Cell Endocrinol.
    2018 Feb 1. pii: S0303-7207(18)30042-X.
  5. Virus-like infection induces human β cell dedifferentiation
    Oshima M, Knoch KP, Diedisheim M, Petzold A, Cattan P, Bugliani M, Marchetti P, Choudhary P, Huang GC, Bornstein SR, Solimena M, Albagli-Curiel O, Scharfmann R.
    JCI Insight. 2018 Feb 8;3(3). pii: 97732
  6. miRNAs regulate development and function of regulatory T-cells in recent onset islet autoimmunity in pre-Type 1 Diabetes
    Simranjeet Kaur and Flemming Pociot. Editorial Comment on: Serr I, Scherm MG, Zahm AM, et al. A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes.
    Sci Transl Med 2018;10:pii eaag1782
  7. Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood.
    Lietzén N, Cheng L, Moulder R, Siljander H, Laajala E, Härkönen T, Peet A, Vehtari A, Tillmann V, Knip M, Lähdesmäki H, Lahesmaa R.
    Sci Rep, 2018 Apr 12 ;8(1):5883. doi: 10.1038/s41598-018-24019-5.
  8. IFNa induces a preferential long-lasting expression of MHC cells I in human pancreatic beta cells.
    Coomans de Brachene, Dos Santos R, Marroqui L, Colli ML, Marselli L, Mirmira RG, Marchetti P, Eizirik DL
    Diabetologia, 61:636–640, 2018
  9. A SRp55-regulated alternative splicing network controls pancreatic beta cell survival and function.
    Juan-Mateu J, Alvelos MI, Turatsinze JV, Villate O, Lizarraga-Mollinedo E, Grieco FA, Marroquí L, Bugliani M, Marchetti P, Eizirik DL
    Diabetes, 67: 423-436, 2018
  10. Autoreactive T effector memory differentiation mirrors β-cell function in type 1 diabetes
    Yeo L, Woodwyk A., Sood S., Lorenc A., Eichmann M., Pujol-Autonell I., Melchiotti R., Skowera A., Fidanis E., Dolton G.M., Tungatt K., Sewell A.K., Heck S., Saxena A., Beam C.A., Peakman M.
    The Journal of clinical investigation, 2018 May 31. pii: 120555. doi: 10.1172/JCI120555
  11. Frequent Monitoring of C-peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home.
    Willemsen R.H., Burling K., Barker P., Ackland F., Dias R.P., Edge J., Smith A., Todd J., Lopez B., Mander A.P., Guy C., Dunger D.B.
    J Clin Endocrinol Metab. 2018 May 31. doi: 10.1210/jc.2018-00500. [Epub ahead of print]
  12. Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry.
    Lanzinger S, Rosenbauer J, Sugiri D, Schikowski T, Treiber B, Klee D, Rathmann W, Holl RW.
    Diabetologia. 2018 Jun;61(6):1354-1361. doi: 10.1007/s00125-018-4580-8. Epub 2018 Feb 24.
  13. MicroRNAs: markers of β-cell stress and autoimmunity.
    Dotta F, Ventriglia G, Snowhite IV, Pugliese A
    Curr Opin Endocrinol Diabetes Obes. 2018 May 24. doi: 10.1097/MED.0000000000000420. [Epub ahead of print] PMID: 29846238
  14. Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes.
    Tesovnik T, Kovac J, Hovnik T, Dovc K, Bratina N, Battelino T, Trebušak Podkrajšek K.
    JAMA Pediatr. 2018 Jun 21. doi: 10.1001/jamapediatrics.2018.1175. [Epub ahead of print] PMID: 29931032
  15. Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes-A Longitudinal Group-Based Modeling Approach Based on the DPV Registry.
    Prinz N, Schwandt A, Becker M, Denzer C, Flury M, Fritsch M, Galler A, Lemmer A, Papsch M, Reinehr T, Rosenbauer J, Holl RW.
    J Pediatr. 2018 Jun 21. pii: S0022-3476(18)30670-X. doi: 10.1016/j.jpeds.2018.05.014. [Epub ahead of print] PMID: 2993708
  16. Novel minor HLA DR associated antigens in type 1 diabetes.
    Müller D, Telieps T, Eugster A, Weinzierl C, Jolink M, Ziegler AG, Bonifacio E.
    Clin Immunol. 2018 Jul 7. pii: S1521-6616(18)30188-8. doi: 10.1016/j.clim.2018.07.001. [Epub ahead of print] PMID:29990590
  17. MANF protects human pancreatic beta cells against stress-induced cell death.
    Hakonen E, Chandra V, Fogarty CL, Yu NY, Ustinov J, Katayama S, Galli E, Danilova T, Lindholm P, Vartiainen A, Einarsdottir E, Krjutškov K, Kere J, Saarma M, Lindahl M, Otonkoski T.
    Diabetologia. 2018 Jul 21. doi: 10.1007/s00125-018-4687-y. [Epub ahead of print] PMID: 30032427
  18. Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors.
    Gonzalez-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalanne AI, Sebastiani G, Carré A, Pinto S, Culina S, Corcos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R.
    Cell Metab. 2018 Jul 23. pii: S1550-4131(18)30450-9. doi: 10.1016/j.cmet.2018.07.007. [Epub ahead of print] PMID: 30078552
  19. Immunological biomarkers for the development and progression of type 1 diabetes.
    Mathieu C, Lahesmaa R, Bonifacio E, Achenbach P, Tree T.
    Diabetologia. 2018 Sep 12. doi: 10.1007/s00125-018-4726-8. [Epub ahead of print] PMID: 30209538
  20. PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.
    Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM3, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL.
    EBioMedicine. 2018 Sep 27. pii: S2352-3964(18)30398-0. doi: 10.1016/j.ebiom.2018.09.040. [Epub ahead of print] PMID: 30269996
  21. Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative.
    DeSalvo DJ, Miller KM, Hermann JM, Maahs DM, Hofer SE, Clements MA, Lilienthal E, Sherr JL, Tauschmann M, Holl RW, T1D Exchange and DPV Registries.
    Pediatr Diabetes. 2018 Nov;19(7):1271-1275. doi: 10.1111/pedi.12711. Epub 2018 Jul 1. PMID: 29923262
  22. Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes.
    Buitinga M, Callebout A, Marques Câmara Sodré F, Crèvecoeur I, Blahnik-Fagan G, Yang ML, Bygliani M, Arribas-Layton D, Marré M, Cook DP, Waelkens E, Mallone R, Piganelli JD, Marchetti P, Mamula MJ, Derua R, James EA, Mathieu C, Overbergh L
    Diabetes. 2018 Nov;67(11):2337-2348. doi: 10.2337/db18-0295. PMID: 30348823
  23. The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms
    Leete P, Mallone R, Richardson S, Sosenko J, Redondo M, Evans-Molina C
    Curr Diab Rep. 2018 Sep 26;18(11):115. doi: 10.1007/s11892-018-1083-4. PMID: 30259209
  24. Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa.
    Demine S, Balhuizen A, Debaille V, Joosten L, Fereau M, Chilla S, Millard I, Scharfmann R, Egrise D, Goldman S, Marchetti P, Gotthardt M, Laurent S, Burtea C, Eizirik DL
    Molecules. 2018 Aug 21;23(9). pii: E2100. doi: 10.3390/molecules23092100. PMID: 30134599
  25. When one becomes many-Alternative splicing in β-cell function and failure.
    Alvelos MI, Juan-Mateu J, Colli MC, Turatsinze J-V, Eizirik DL
    Diabetes Obes Metab. 2018 Sep;20 Suppl 2:77-87. doi: 10.1111/dom.13388. PMID: 30230174
  26. Biomarkers of islet beta cell stress and death in type 1 diabetes.
    Sims EK, Evans-Mollina C, Tersey SA, Eizirik DL, Mirmira RG
    Diabetologia. 2018 Nov;61(11):2259-2265. doi: 10.1007/s00125-018-4712-1. Epub 2018 Aug 15 PMID: 30112687
  27. Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource.
    Marchetti P , Suleiman M , Marselli L .
    Diabetologia. 2018 Apr;61(4):770-774. doi: 10.1007/s00125-018-4546-x. Epub 2018 Jan 21. PMID: 29354869
  28. Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.
    Balboa D, Saarimäki-Vire J, Borshagovski D, Survila M, Lindholm P, Galli E, Eurola S, Ustinov J, Grym H, Huopio H, Partanen J, Wartiovaara K, Otonkoski T.
    Elife. 2018 Nov 9;7. pii: e38519. doi: 10.7554/eLife.38519. [Epub ahead of print] PubMed PMID: 30412052.
  29. DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signaling pathway
    Dos Santos RS, Marroqui L, Velayios T, Olazogoitia-Garmendia A, Jauregi-Miguel A, Castellanos-Rubio A, Eizirik DL, Castano L, Santin I.
    Diabetologia. 2018 Nov 26. doi: 10.1007/s00125-018-4782-0. [Epub ahead of print] PMID: 30478640
  30. Succinylated gelatin improves the theranostic potential of radiolabeled exendin-4 in insulinoma patients.
    Buitinga M, Jansen T, van der KroonvI, Woliner-van der Weg W, Boss M, Janssen M, Aarntzen E, Wild MBD, Visser E, Brom M, Gotthardt M.
    J Nucl Med. 2018 Nov 30. pii: jnumed.118.219980. doi: 10.2967/jnumed.118.219980. [Epub ahead of print] PMID:30504139
  31. MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes
    Nigi L, Grieco GE, Ventriglia G, Brusco N, Mancarella F, Formichi C, Dotta F, Sebastiani G.
    Int J Mol Sci. 2018 Nov 22;19(12). pii: E3705. doi: 10.3390/ijms19123705. PMID: 30469501
  32. Risk factors for decline in renal function among young adults with type 1 diabetes
    Schwandt A, Bergis D, Denkinger M, Gollisch KSC, Sandig D, Stingl H, Zimny S, Holl RW.
    J Diabetes Complications. 2018 Oct;32(10):940-946. doi: 10.1016/j.jdiacomp.2018.07.007. Epub 2018 Jul 19. PMID: 30055905
  33. Proinsulin-mediated induction of type 1 diabetes in HLA-DR4-transgenic mice.
    Verhagen J, Smith EL, Whettlock EM, Macintyre B, Peakman M.
    Sci Rep. 2018 Sep 20;8(1):14106. doi: 10.1038/s41598-018-32546-4.

Publications 2017

  1. Understanding type 1 diabetes through proteomics
    Crèvecour I, Vig S, Mathieu C, Overbergh L.
    Expert Rev Proteomics. 2017 Jul;14(7):571-580.
  2. New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?
    Harbige J, Eichmann M, Peakman
    M. J Autoimmun. 2017 Aug 10. pii: S0896-8411(17)30389-X. Review
  3. Protective role of complement C3 against cytokine-mediated β-cell apoptosis.
    Reinaldo S. Dos Santos, Laura Marroqui, Fabio A. Grieco, Lorella Marselli, Mara Suleiman, Stefan R. Henz, Piero Marchetti, Rasmus Wernersson, Decio L. Eizirik.
    Endocrinology 2017 DOI: 10.1210/en.2017-00104
  4. Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes
    Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik
    Diabetologia (2017) | DOI:10.1007/s00125-016-4201-3
  5. MicroRNAs miR-23a-3p, miR-23b-3p,and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic b-Cells
    Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta and Décio L. Eizirik
    Diabetes 2017;66:100–112 | DOI: 10.2337/db16-0592
  6. Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells. Diabetes.
    Meyerovich K, Violato NM, Fukaya M, Dirix V, Pachera N, Marselli L, Marchetti P, Strasser A, Eizirik DL, Cardozo AK.
    2017 Sep;66(9):2446-2458. doi: 10.2337/db16-1252. Epub 2017 Jun 30.
  7. Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).
    Cunha DA, Cito M, Grieco FA, Cosentino C, Danilova T, Ladrière L, Lindahl M, Domanskyi A, Bugliani M, Marchetti P, Eizirik DL, Cnop M.
    J Biol Chem. 2017 Sep 8;292(36):14977-14988. doi: 10.1074/jbc.M116.769877. Epub 2017 Jul 11.
  8. A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
    Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, Xavier C, Villate O, Millard I, Egrise D, Capito C, Scharfmann R, In't Veld P, Marchetti P, Muyldermans S, Goldman S, Lahoutte T, Bouwens L, Eizirik DL, Devoogdt N.
    Sci Rep. 2017 Nov 9;7(1):15130. doi: 10.1038/s41598-017-15417-2. PMID:29123178
  9. SRp55 Regulates a Splicing Network that Controls Human Pancreatic Beta Cell Function and Survival. Diabetes.
    Juan-Mateu J, Alvelos MI, Turatsinze JV, Villate O, Lizarraga-Mollinedo E, Grieco FA, Marroquí L, Bugliani M, Marchetti P, Eizirik DL.
    2017 Dec 15. pii: db170736.
  10. Welche Patienten aus der Routinebetreuung verwenden das neue Insulin-Analogon Glargin U300 im Vergleich zu Patientenmit Glargin U100?
    Bohn B, Bramlage P, Wagner C, Kaltheuner M, Welp R, Sziegoleit S, Zimmermann A, Reuter HM, Hummel M, Holl RW, Danne T
    Wien Med Wochenschr, DOI 10.1007/s10354-017-0589-8, 2017
  11. Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort
    Reinauer C, Bollow E, Fröhlich-Reiterer E, Laubner K, Bergis D, Schöfl, C, Kempe HP, Hummel M, Hennes P, Gollisch K, Haberland H, Datz N, Meissner T, Holl RW
    Exp Clin Endocrinol Diabetes, 125(10):661-668, 2017
  12. The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype
    Reinauer C, Rosenbauer J, Bächle C, Herder C, Roden M, Ellard S, De-Franco E, Karges B, Holl RW, Enczmann J, Meissner T
    Genes, 8(5):146, 2017
  13. Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach
    Schwandt A, Hermann JM, , Rosenbauer J, Boettcher C, Dunstheimer D, Grulich-Henn J, Kuss O, Rami-Merhar B, Vogel C, Holl RW on behalf of the DPV initiative
    Diabetes Care, 40:309-316, 2017
  14. Europe has to step up its efforts to produce innovative and safe diabetes technology.
    Cnop M, Klupa T, Tentolouris N, Novials A, Burcelin R, van Eimeren M.
    Diabetologia. 2017 Dec;60(12):2532-2533. doi: 10.1007/s00125-017-4455-4. Epub 2017 Sep 24. No abstract available.
    PMID: 28942556

  15. Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials
    Suwandi JS, Nikolic T, Roep BO.
    Front Immunol. 2017 Nov 22;8:1598. doi: 10.3389/fimmu.2017.01598. eCollection 2017. PMID: 29250062

Publications 2016

  1. Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/ Austrian Registry: A Group-Based Modeling Approach
    Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, and Reinhard W. Holl, on behalf of the DPV Initiative
    Diabetes Care 2016 Dec 22. | DOI: 10.2337/dc16-1625