Publications

Publications 2018

1. Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis
Paula FMM, Leite NC, Borck PC, Freitas-Dias R, Cnop M, Chacon-Mikahil MPT, Cavaglieri CR, Marchetti P, Boschero AC, Zoppi CC, Eizirik DL. FASEB J.
2018 Jan 3:fj201700710R.



2. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.
Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013.



3. Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicentre DPV study on 24,011 patients from Germany, Austria, or Luxembourg
Bohn B, Mönkemöller K, Hilgard D, Dost A, Schwab KO, Lilienthal E, Hammer E, Hake K, Fritsch M, Gohlke B, de Beaufort C, Holl RW; DPV-initiative.
Pediatr Diabetes. 2018 Feb 7.



4. DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes
Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, Grano F, Cardarelli F, Boggi U, Vistoli F, Filipponi F, De Simone P, Marselli L, De Tata V, Ahren B, Eizirik DL, Marchetti P.. Mol Cell Endocrinol.
2018 Feb 1. pii: S0303-7207(18)30042-X.



5. Virus-like infection induces human β cell dedifferentiation
Oshima M, Knoch KP, Diedisheim M, Petzold A, Cattan P, Bugliani M, Marchetti P, Choudhary P, Huang GC, Bornstein SR, Solimena M, Albagli-Curiel O, Scharfmann R.
JCI Insight. 2018 Feb 8;3(3). pii: 97732



6. miRNAs regulate development and function of regulatory T-cells in recent onset islet autoimmunity in pre-Type 1 Diabetes
Simranjeet Kaur and Flemming Pociot. Editorial Comment on: Serr I, Scherm MG, Zahm AM, et al. A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes.
Sci Transl Med 2018;10:pii eaag1782



Publications 2017

1. Understanding type 1 diabetes through proteomics
Crèvecoeur I, Vig S, Mathieu C, Overbergh L.
Expert Rev Proteomics. 2017 Jul;14(7):571-580.



2. New insights into non-conventional epitopes as T cell targets:
The missing link for breaking immune tolerance in autoimmune disease?

Harbige J, Eichmann M, Peakman
M. J Autoimmun. 2017 Aug 10. pii: S0896-8411(17)30389-X. Review



3. Protective role of complement C3 against cytokine-mediated β-cell apoptosis.
Reinaldo S. Dos Santos, Laura Marroqui, Fabio A. Grieco, Lorella Marselli, Mara Suleiman, Stefan R. Henz,
Piero Marchetti, Rasmus Wernersson, Decio L. Eizirik.
Endocrinology 2017 DOI: 10.1210/en.2017-00104



4. Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli,
Piero Marchetti, Decio L. Eizirik
Diabetologia (2017) | DOI:10.1007/s00125-016-4201-3



5. MicroRNAs miR-23a-3p, miR-23b-3p,and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic b-Cells Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay,
Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta and Décio L. Eizirik
Diabetes 2017;66:100–112 | DOI: 10.2337/db16-0592



6. Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells. Diabetes.
Meyerovich K, Violato NM, Fukaya M, Dirix V, Pachera N, Marselli L, Marchetti P, Strasser A, Eizirik DL, Cardozo AK.
2017 Sep;66(9):2446-2458. doi: 10.2337/db16-1252. Epub 2017 Jun 30.



7. Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).
Cunha DA, Cito M, Grieco FA, Cosentino C, Danilova T, Ladrière L, Lindahl M, Domanskyi A, Bugliani M, Marchetti P, Eizirik DL, Cnop M.
J Biol Chem. 2017 Sep 8;292(36):14977-14988. doi: 10.1074/jbc.M116.769877. Epub 2017 Jul 11.



8. Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis
Paula FMM, Leite NC, Borck PC, Freitas-Dias R, Cnop M, Chacon-Mikahil MPT, Cavaglieri CR, Marchetti P, Boschero AC, Zoppi CC, Eizirik DL
FASEB J. 2017 Nov 13. pii: fj.201700710R. doi: 10.1096/fj.201700710R. PMID:29133342



9. A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, Xavier C, Villate O, Millard I, Egrise D, Capito C, Scharfmann R, In't Veld P, Marchetti P, Muyldermans S, Goldman S, Lahoutte T, Bouwens L, Eizirik DL, Devoogdt N.
Sci Rep. 2017 Nov 9;7(1):15130. doi: 10.1038/s41598-017-15417-2. PMID:29123178

10. SRp55 Regulates a Splicing Network that Controls Human Pancreatic Beta Cell Function and Survival. Diabetes.
Juan-Mateu J, Alvelos MI, Turatsinze JV, Villate O, Lizarraga-Mollinedo E, Grieco FA, Marroquí L, Bugliani M, Marchetti P, Eizirik DL.
2017 Dec 15. pii: db170736.

Publications 2016

1. Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/ Austrian Registry: A Group-Based Modeling Approach Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, and Reinhard W. Holl, on behalf of the DPV Initiative
Diabetes Care 2016 Dec 22. | DOI: 10.2337/dc16-1625



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