Our publications

Publications 2018

  1. Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis
    Paula FMM, Leite NC, Borck PC, Freitas-Dias R, Cnop M, Chacon-Mikahil MPT, Cavaglieri CR, Marchetti P, Boschero AC, Zoppi CC, Eizirik DL. FASEB J.
    2018 Jan 3:fj201700710R.
  2. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
    Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.
    Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013.
  3. Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicentre DPV study on 24,011 patients from Germany, Austria, or Luxembourg
    Bohn B, Mönkemöller K, Hilgard D, Dost A, Schwab KO, Lilienthal E, Hammer E, Hake K, Fritsch M, Gohlke B, de Beaufort C, Holl RW; DPV-initiative.
    Pediatr Diabetes. 2018 Feb 7.
  4. DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes
    Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, Grano F, Cardarelli F, Boggi U, Vistoli F, Filipponi F, De Simone P, Marselli L, De Tata V, Ahren B, Eizirik DL, Marchetti P.. Mol Cell Endocrinol.
    2018 Feb 1. pii: S0303-7207(18)30042-X.
  5. Virus-like infection induces human β cell dedifferentiation
    Oshima M, Knoch KP, Diedisheim M, Petzold A, Cattan P, Bugliani M, Marchetti P, Choudhary P, Huang GC, Bornstein SR, Solimena M, Albagli-Curiel O, Scharfmann R.
    JCI Insight. 2018 Feb 8;3(3). pii: 97732
  6. miRNAs regulate development and function of regulatory T-cells in recent onset islet autoimmunity in pre-Type 1 Diabetes
    Simranjeet Kaur and Flemming Pociot. Editorial Comment on: Serr I, Scherm MG, Zahm AM, et al. A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes.
    Sci Transl Med 2018;10:pii eaag1782
  7. Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood.
    Lietzén N, Cheng L, Moulder R, Siljander H, Laajala E, Härkönen T, Peet A, Vehtari A, Tillmann V, Knip M, Lähdesmäki H, Lahesmaa R.
    Sci Rep, 2018 Apr 12 ;8(1):5883. doi: 10.1038/s41598-018-24019-5.
  8. IFNa induces a preferential long-lasting expression of MHC cells I in human pancreatic beta cells.
    Coomans de Brachene, Dos Santos R, Marroqui L, Colli ML, Marselli L, Mirmira RG, Marchetti P, Eizirik DL
    Diabetologia, 61:636–640, 2018
  9. A SRp55-regulated alternative splicing network controls pancreatic beta cell survival and function.
    Juan-Mateu J, Alvelos MI, Turatsinze JV, Villate O, Lizarraga-Mollinedo E, Grieco FA, Marroquí L, Bugliani M, Marchetti P, Eizirik DL
    Diabetes, 67: 423-436, 2018
  10. Autoreactive T effector memory differentiation mirrors β-cell function in type 1 diabetes
    Yeo L, Woodwyk A., Sood S., Lorenc A., Eichmann M., Pujol-Autonell I., Melchiotti R., Skowera A., Fidanis E., Dolton G.M., Tungatt K., Sewell A.K., Heck S., Saxena A., Beam C.A., Peakman M.
    The Journal of clinical investigation, 2018 May 31. pii: 120555. doi: 10.1172/JCI120555
  11. Frequent Monitoring of C-peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home.
    Willemsen R.H., Burling K., Barker P., Ackland F., Dias R.P., Edge J., Smith A., Todd J., Lopez B., Mander A.P., Guy C., Dunger D.B.
    J Clin Endocrinol Metab. 2018 May 31. doi: 10.1210/jc.2018-00500. [Epub ahead of print]
  12. Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry.
    Lanzinger S, Rosenbauer J, Sugiri D, Schikowski T, Treiber B, Klee D, Rathmann W, Holl RW.
    Diabetologia. 2018 Jun;61(6):1354-1361. doi: 10.1007/s00125-018-4580-8. Epub 2018 Feb 24.
  13. MicroRNAs: markers of β-cell stress and autoimmunity.
    Dotta F, Ventriglia G, Snowhite IV, Pugliese A
    Curr Opin Endocrinol Diabetes Obes. 2018 May 24. doi: 10.1097/MED.0000000000000420. [Epub ahead of print] PMID: 29846238
  14. Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes.
    Tesovnik T, Kovac J, Hovnik T, Dovc K, Bratina N, Battelino T, Trebušak Podkrajšek K.
    JAMA Pediatr. 2018 Jun 21. doi: 10.1001/jamapediatrics.2018.1175. [Epub ahead of print] PMID: 29931032
  15. Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes-A Longitudinal Group-Based Modeling Approach Based on the DPV Registry.
    Prinz N, Schwandt A, Becker M, Denzer C, Flury M, Fritsch M, Galler A, Lemmer A, Papsch M, Reinehr T, Rosenbauer J, Holl RW.
    J Pediatr. 2018 Jun 21. pii: S0022-3476(18)30670-X. doi: 10.1016/j.jpeds.2018.05.014. [Epub ahead of print] PMID: 2993708
  16. Novel minor HLA DR associated antigens in type 1 diabetes.
    Müller D, Telieps T, Eugster A, Weinzierl C, Jolink M, Ziegler AG, Bonifacio E.
    Clin Immunol. 2018 Jul 7. pii: S1521-6616(18)30188-8. doi: 10.1016/j.clim.2018.07.001. [Epub ahead of print] PMID:29990590
  17. MANF protects human pancreatic beta cells against stress-induced cell death.
    Hakonen E, Chandra V, Fogarty CL, Yu NY, Ustinov J, Katayama S, Galli E, Danilova T, Lindholm P, Vartiainen A, Einarsdottir E, Krjutškov K, Kere J, Saarma M, Lindahl M, Otonkoski T.
    Diabetologia. 2018 Jul 21. doi: 10.1007/s00125-018-4687-y. [Epub ahead of print] PMID: 30032427
  18. Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors.
    Gonzalez-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalanne AI, Sebastiani G, Carré A, Pinto S, Culina S, Corcos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R.
    Cell Metab. 2018 Jul 23. pii: S1550-4131(18)30450-9. doi: 10.1016/j.cmet.2018.07.007. [Epub ahead of print] PMID: 30078552
  19. Immunological biomarkers for the development and progression of type 1 diabetes.
    Mathieu C, Lahesmaa R, Bonifacio E, Achenbach P, Tree T.
    Diabetologia. 2018 Sep 12. doi: 10.1007/s00125-018-4726-8. [Epub ahead of print] PMID: 30209538
  20. PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.
    Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM3, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL.
    EBioMedicine. 2018 Sep 27. pii: S2352-3964(18)30398-0. doi: 10.1016/j.ebiom.2018.09.040. [Epub ahead of print] PMID: 30269996
  21. Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative.
    DeSalvo DJ, Miller KM, Hermann JM, Maahs DM, Hofer SE, Clements MA, Lilienthal E, Sherr JL, Tauschmann M, Holl RW, T1D Exchange and DPV Registries.
    Pediatr Diabetes. 2018 Nov;19(7):1271-1275. doi: 10.1111/pedi.12711. Epub 2018 Jul 1. PMID: 29923262
  22. Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes.
    Buitinga M, Callebout A, Marques Câmara Sodré F, Crèvecoeur I, Blahnik-Fagan G, Yang ML, Bygliani M, Arribas-Layton D, Marré M, Cook DP, Waelkens E, Mallone R, Piganelli JD, Marchetti P, Mamula MJ, Derua R, James EA, Mathieu C, Overbergh L
    Diabetes. 2018 Nov;67(11):2337-2348. doi: 10.2337/db18-0295. PMID: 30348823
  23. The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms
    Leete P, Mallone R, Richardson S, Sosenko J, Redondo M, Evans-Molina C
    Curr Diab Rep. 2018 Sep 26;18(11):115. doi: 10.1007/s11892-018-1083-4. PMID: 30259209
  24. Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa.
    Demine S, Balhuizen A, Debaille V, Joosten L, Fereau M, Chilla S, Millard I, Scharfmann R, Egrise D, Goldman S, Marchetti P, Gotthardt M, Laurent S, Burtea C, Eizirik DL
    Molecules. 2018 Aug 21;23(9). pii: E2100. doi: 10.3390/molecules23092100. PMID: 30134599
  25. When one becomes many-Alternative splicing in β-cell function and failure.
    Alvelos MI, Juan-Mateu J, Colli MC, Turatsinze J-V, Eizirik DL
    Diabetes Obes Metab. 2018 Sep;20 Suppl 2:77-87. doi: 10.1111/dom.13388. PMID: 30230174
  26. Biomarkers of islet beta cell stress and death in type 1 diabetes.
    Sims EK, Evans-Mollina C, Tersey SA, Eizirik DL, Mirmira RG
    Diabetologia. 2018 Nov;61(11):2259-2265. doi: 10.1007/s00125-018-4712-1. Epub 2018 Aug 15 PMID: 30112687
  27. Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource.
    Marchetti P , Suleiman M , Marselli L .
    Diabetologia. 2018 Apr;61(4):770-774. doi: 10.1007/s00125-018-4546-x. Epub 2018 Jan 21. PMID: 29354869
  28. Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes.
    Balboa D, Saarimäki-Vire J, Borshagovski D, Survila M, Lindholm P, Galli E, Eurola S, Ustinov J, Grym H, Huopio H, Partanen J, Wartiovaara K, Otonkoski T.
    Elife. 2018 Nov 9;7. pii: e38519. doi: 10.7554/eLife.38519. [Epub ahead of print] PubMed PMID: 30412052.

Publications 2017

  1. Understanding type 1 diabetes through proteomics
    Crèvecour I, Vig S, Mathieu C, Overbergh L.
    Expert Rev Proteomics. 2017 Jul;14(7):571-580.
  2. New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?
    Harbige J, Eichmann M, Peakman
    M. J Autoimmun. 2017 Aug 10. pii: S0896-8411(17)30389-X. Review
  3. Protective role of complement C3 against cytokine-mediated β-cell apoptosis.
    Reinaldo S. Dos Santos, Laura Marroqui, Fabio A. Grieco, Lorella Marselli, Mara Suleiman, Stefan R. Henz, Piero Marchetti, Rasmus Wernersson, Decio L. Eizirik.
    Endocrinology 2017 DOI: 10.1210/en.2017-00104
  4. Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes
    Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik
    Diabetologia (2017) | DOI:10.1007/s00125-016-4201-3
  5. MicroRNAs miR-23a-3p, miR-23b-3p,and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic b-Cells
    Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta and Décio L. Eizirik
    Diabetes 2017;66:100–112 | DOI: 10.2337/db16-0592
  6. Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells. Diabetes.
    Meyerovich K, Violato NM, Fukaya M, Dirix V, Pachera N, Marselli L, Marchetti P, Strasser A, Eizirik DL, Cardozo AK.
    2017 Sep;66(9):2446-2458. doi: 10.2337/db16-1252. Epub 2017 Jun 30.
  7. Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).
    Cunha DA, Cito M, Grieco FA, Cosentino C, Danilova T, Ladrière L, Lindahl M, Domanskyi A, Bugliani M, Marchetti P, Eizirik DL, Cnop M.
    J Biol Chem. 2017 Sep 8;292(36):14977-14988. doi: 10.1074/jbc.M116.769877. Epub 2017 Jul 11.
  8. A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
    Balhuizen A, Massa S, Mathijs I, Turatsinze JV, De Vos J, Demine S, Xavier C, Villate O, Millard I, Egrise D, Capito C, Scharfmann R, In't Veld P, Marchetti P, Muyldermans S, Goldman S, Lahoutte T, Bouwens L, Eizirik DL, Devoogdt N.
    Sci Rep. 2017 Nov 9;7(1):15130. doi: 10.1038/s41598-017-15417-2. PMID:29123178
  9. SRp55 Regulates a Splicing Network that Controls Human Pancreatic Beta Cell Function and Survival. Diabetes.
    Juan-Mateu J, Alvelos MI, Turatsinze JV, Villate O, Lizarraga-Mollinedo E, Grieco FA, Marroquí L, Bugliani M, Marchetti P, Eizirik DL.
    2017 Dec 15. pii: db170736.
  10. Welche Patienten aus der Routinebetreuung verwenden das neue Insulin-Analogon Glargin U300 im Vergleich zu Patientenmit Glargin U100?
    Bohn B, Bramlage P, Wagner C, Kaltheuner M, Welp R, Sziegoleit S, Zimmermann A, Reuter HM, Hummel M, Holl RW, Danne T
    Wien Med Wochenschr, DOI 10.1007/s10354-017-0589-8, 2017
  11. Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort
    Reinauer C, Bollow E, Fröhlich-Reiterer E, Laubner K, Bergis D, Schöfl, C, Kempe HP, Hummel M, Hennes P, Gollisch K, Haberland H, Datz N, Meissner T, Holl RW
    Exp Clin Endocrinol Diabetes, 125(10):661-668, 2017
  12. The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype
    Reinauer C, Rosenbauer J, Bächle C, Herder C, Roden M, Ellard S, De-Franco E, Karges B, Holl RW, Enczmann J, Meissner T
    Genes, 8(5):146, 2017
  13. Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach
    Schwandt A, Hermann JM, , Rosenbauer J, Boettcher C, Dunstheimer D, Grulich-Henn J, Kuss O, Rami-Merhar B, Vogel C, Holl RW on behalf of the DPV initiative
    Diabetes Care, 40:309-316, 2017
  14. Europe has to step up its efforts to produce innovative and safe diabetes technology.
    Cnop M, Klupa T, Tentolouris N, Novials A, Burcelin R, van Eimeren M.
    Diabetologia. 2017 Dec;60(12):2532-2533. doi: 10.1007/s00125-017-4455-4. Epub 2017 Sep 24. No abstract available.
    PMID: 28942556

Publications 2016

  1. Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/ Austrian Registry: A Group-Based Modeling Approach
    Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, and Reinhard W. Holl, on behalf of the DPV Initiative
    Diabetes Care 2016 Dec 22. | DOI: 10.2337/dc16-1625