For people with an increased T1D risk

Find out how people with an increased risk of developing type 1 diabetes can benefit from INNODIA research

At present, the risk of family members in developing the disease is based on the detection of auto-antibodies against beta-cell proteins, that are detectable in your blood. Such antibodies are a type of protein produced by cells in the immune system that can attack healthy cells in the body because they recognize them as ‘foreign’ cells.

The risk of developing type 1 diabetes increases with the number of autoantibodies detected. Importantly, these autoantibodies can be present for many years before someone develops T1D. They often appear in the first few years of life, even in people who do not develop T1D until they are adults. Therefore, more fundamental research is necessary in order to find more and better biomarkers for predicting T1D.

First degree relatives of people with type 1 diabetes

INNODIA analyzes blood, urine and stool samples of first-degree relatives (brothers, sisters, parents or children) of people with T1D because we know that relatives share genes with their family member and therefore may be at greater risk of developing the disease.

People with an increased risk in the general population

The project now also welcomes ALL autoantibody positive people with an increased risk of developing type 1 diabetes, detected through screening programs outside INNODIA. Even people without a family member with T1D.

Participation in both observational studies is completely voluntary. If you agree to take part you will be asked to sign a consent form. However, you are free to change your mind and leave the study at any time without giving a reason. If you choose not to take part or you want to leave the study, your future medical treatment and care will not be affected in any way.

Who can participate?

You qualify to take part in the INNODIA observational study if you:

Are between the ages of 1 and 45 years and have a parent, brother/sister, or child with T1D


Are between the ages of 1 and 45 years and have already tested positive for at least one T1D related autoantibody in a project outside INNODIA

How can I participate?

We encourage first-degree relatives of people with type 1 diabetes (no matter how long ago diagnosis took place) to take part in the INNODIA study, as well as people from the general public who already tested autoantibody positive in another project.

What happens to my samples

Research related publications

Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1.

Gene expression signatures of target issues in type 1 diabetes.

A humanized mouse Strain that develops spontaneously immune-mediated diabetes.

Targeting protein changes to cure autoimmune diseases: how far are we from clinical translation?

MDA5 is involved in type 1 diabetes pathogenesis; what does that mean?